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Issue 48, 2020
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Regioselective synthesis and anticancer evaluation of H2O2-activable nucleosides

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Abstract

We describe here the design, synthesis, and biological evaluation of H2O2-activatable nucleosides via an efficient and regioselective functionalization of unprotected precursors. Biological evaluation of a H2O2-specific responsive prodrug of gemecitabin demonstrates an extremely fast activation, low toxicity and enhanced anticancer effects in two cell lines.

Graphical abstract: Regioselective synthesis and anticancer evaluation of H2O2-activable nucleosides

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Supplementary files

Article information


Submitted
27 Mar 2020
Accepted
18 May 2020
First published
18 May 2020

Chem. Commun., 2020,56, 6484-6487
Article type
Communication

Regioselective synthesis and anticancer evaluation of H2O2-activable nucleosides

Y. Sun, L. Liu and L. Cheng, Chem. Commun., 2020, 56, 6484
DOI: 10.1039/D0CC02245D

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