Jump to main content
Jump to site search
PLANNED MAINTENANCE Close the message box

Scheduled maintenance work on Wednesday 21st October 2020 from 07:00 AM to 07:00 PM (BST).

During this time our website performance may be temporarily affected. We apologise for any inconvenience this might cause and thank you for your patience.


Issue 66, 2020
Previous Article Next Article

Preparation of labeled aromatic amino acids via late-stage 18F-fluorination of chiral nickel and copper complexes

Author affiliations

Abstract

A general protocol for the preparation of 18F-labeled AAAs and α-methyl-AAAs applying alcohol-enhanced Cu-mediated radiofluorination of Bpin-substituted chiral complexes using Ni/Cu-BPX templates as double protecting groups is reported. The chiral auxiliaries are easily accessible from commercially available starting materials in a few synthetic steps. The versatility of the method was demonstrated by the high-yielding preparation of a series of [18F]F-AAAs and the successful implementation of the protocol into automated radiosynthesis modules.

Graphical abstract: Preparation of labeled aromatic amino acids via late-stage 18F-fluorination of chiral nickel and copper complexes

Back to tab navigation

Supplementary files

Article information


Submitted
26 Mar 2020
Accepted
09 Jul 2020
First published
09 Jul 2020

Chem. Commun., 2020,56, 9505-9508
Article type
Communication

Preparation of labeled aromatic amino acids via late-stage 18F-fluorination of chiral nickel and copper complexes

A. Craig, N. Kolks, E. A. Urusova, J. Zischler, M. Brugger, H. Endepols, B. Neumaier and B. D. Zlatopolskiy, Chem. Commun., 2020, 56, 9505
DOI: 10.1039/D0CC02223C

Social activity

Search articles by author

Spotlight

Advertisements