Issue 43, 2020

Synthesis of benzyl sulfides via substitution reaction at the sulfur of phosphinic acid thioesters

Abstract

An ambident electrophilicity of phosphinic acid thioesters is disclosed. Unexpected carbon–sulfur bond formation took place in the reaction between phosphinic acid thioesters and benzyl Grignard reagents. The developed method for benzyl sulfides has a wide substrate scope and was applicable for the synthesis of a drug analog.

Graphical abstract: Synthesis of benzyl sulfides via substitution reaction at the sulfur of phosphinic acid thioesters

Supplementary files

Article information

Article type
Communication
Submitted
19 Mar 2020
Accepted
16 Apr 2020
First published
16 Apr 2020
This article is Open Access
Creative Commons BY-NC license

Chem. Commun., 2020,56, 5771-5774

Synthesis of benzyl sulfides via substitution reaction at the sulfur of phosphinic acid thioesters

Y. Nishiyama, T. Hosoya and S. Yoshida, Chem. Commun., 2020, 56, 5771 DOI: 10.1039/D0CC02039G

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