Issue 54, 2020
From the journal:

Chemical Communications

Ultrasound-degradable serum albumin nanoplatform for in situ controlled drug release†

Jianjun Du, ORCID logo *ab   Yu Zhang,a   Haoying Ge,a   Chao Shi,a   Saran Long,ab   Wen Sun, ORCID logo ab   Jiangli Fan ORCID logo ab  and  Xiaojun Peng ORCID logo ab  

* Corresponding authors

a State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116024, China
E-mail: dujj@dlut.edu.cn

b Shenzhen Research Institute, Dalian University of Technology, Nanshan District, Shenzhen 518057, P. R. China

Abstract

In this work, bovine serum albumin-based nanoparticles, BSA-ACVA-DOX NPs, were fabricated for ultrasound-driven drug release, and exhibited excellent tissue penetration. Moreover, a pulsatile release of DOX in vivo could be programmed by in vitro (i.e., remotely) switching the ultrasound on and off.

Graphical abstract: Ultrasound-degradable serum albumin nanoplatform for in situ controlled drug release

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Article information

DOI
https://doi.org/10.1039/D0CC01937B
Article type
Communication
Submitted
14 Mar 2020
Accepted
20 May 2020
First published
05 Jun 2020

Chem. Commun., 2020,56, 7503-7506

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Ultrasound-degradable serum albumin nanoplatform for in situ controlled drug release

J. Du, Y. Zhang, H. Ge, C. Shi, S. Long, W. Sun, J. Fan and X. Peng, Chem. Commun., 2020, 56, 7503 DOI: 10.1039/D0CC01937B

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