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Issue 54, 2020
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Unveiling the reaction mechanism of novel copper N-alkylated tetra-azacyclophanes with outstanding superoxide dismutase activity

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Abstract

Quantum chemical and multiscale calculations reveal the mechanistic pathway of two superoxide dismutase mimetic N-alkylated tetra-azacyclophane copper complexes with remarkable activity. The arrangement of the binding site afforded by the bulky alkyl substituents and the coordinated water molecule as a proton source play key roles in the reaction mechanism.

Graphical abstract: Unveiling the reaction mechanism of novel copper N-alkylated tetra-azacyclophanes with outstanding superoxide dismutase activity

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Article information


Submitted
13 Mar 2020
Accepted
28 May 2020
First published
28 May 2020

This article is Open Access

Chem. Commun., 2020,56, 7511-7514
Article type
Communication

Unveiling the reaction mechanism of novel copper N-alkylated tetra-azacyclophanes with outstanding superoxide dismutase activity

Á. Martínez-Camarena, P. A. Sánchez-Murcia, S. Blasco, L. González and E. García-España, Chem. Commun., 2020, 56, 7511
DOI: 10.1039/D0CC01926G

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