Rational ligand choice extends the SABRE substrate scope

Johannes F. P. Colell; Angus W. J. Logan; Zijian Zhou; Jacob R. Lindale; Raul Laasner; Roman V. Shchepin; Eduard Y. Chekmenev; Volker Blum; Warren S. Warren; Steven J. Malcolmson; Thomas Theis

doi:10.1039/D0CC01330G

Rational ligand choice extends the SABRE substrate scope†

Johannes F. P. Colell,

‡^a Angus W. J. Logan,

‡^a Zijian Zhou,

^a Jacob R. Lindale,^a Raul Laasner,

^b Roman V. Shchepin,^c Eduard Y. Chekmenev,

^de Volker Blum,

^ab Warren S. Warren,*^af Steven J. Malcolmson

*^a and Thomas Theis

*^agh

Author affiliations

* Corresponding authors

^a Department of Chemistry, Duke University, Durham, NC 27708, USA
E-mail: steven.malcolmson@duke.edu, warren.warren@duke.edu

^b Department of Mechanical Engineering and Materials Science, Duke University, Durham, NC 27708, USA

^c Department of Chemistry, Biology, and Health Sciences, South Dakota School of Mines and Technology, Rapid City, South Dakota 57701, USA

^d Russian Academy of Sciences, Leninskiy Prospekt 14, 119991 Moscow, Russia

^e Department of Chemistry, Integrative Biosciences (IBio), Karmanos Cancer Institute (KCI), Wayne State University, Detroit, MI 48202, USA

^f Departments of Physics, Radiology and Biomedical Engineering, Duke University, Durham, NC 27707, USA

^g Department of Chemistry, North Carolina State University, Raleigh, NC 27695, USA
E-mail: ttheis@ncsu.edu

^h Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Chapel Hill, NC, USA

Abstract

Here we report on chelating ligands for Signal Amplification By Reversible Exchange (SABRE) catalysts that permit hyperpolarisation on otherwise sterically hindered substrates. We demonstrate ¹H enhancements of ∼100-fold over 8.5 T thermal for 2-substituted pyridines, and smaller, yet significant enhancements for provitamin B₆ and caffeine. We also show ¹⁵N-enhancements of ∼1000-fold and ¹⁹F-enhancements of 30-fold.

Chemical Communications

Rational ligand choice extends the SABRE substrate scope†

Abstract

Supplementary files

Article information

Download Citation

Author version available

Permissions

Rational ligand choice extends the SABRE substrate scope

Social activity

Search articles by author

Spotlight

Advertisements