Issue 31, 2020

Design of potent Mincle signalling agonists based on an alkyl β-glucoside template

Abstract

The innate immune receptor Mincle senses lipid-based molecules derived from pathogens, commensals and altered self. Based on emerging structure–activity relationships we design simple alkyl 6-O-acyl-β-D-glucosides that are effective agonists of Mincle and signal with potency on par with the prototypical ligand trehalose dimycolate.

Graphical abstract: Design of potent Mincle signalling agonists based on an alkyl β-glucoside template

Supplementary files

Article information

Article type
Communication
Submitted
24 Jan 2020
Accepted
09 Mar 2020
First published
10 Mar 2020

Chem. Commun., 2020,56, 4292-4295

Design of potent Mincle signalling agonists based on an alkyl β-glucoside template

D. G. M. Smith, Y. Hosono, M. Nagata, S. Yamasaki and S. J. Williams, Chem. Commun., 2020, 56, 4292 DOI: 10.1039/D0CC00670J

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