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Issue 56, 2020
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The biothiol-triggered organotrisulfide-based self-immolative fluorogenic donors of hydrogen sulfide enable lysosomal trafficking

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Abstract

Biothiol-reactive organotrisulfide-based self-immolative fluorogenic donors of H2S are rationally designed for the efficient monitoring of intracellular and lysosomal trafficking of H2S with a concomitant turn-on fluorescence. The non-toxic nature of the donors with a sustained release of H2S will certainly be helpful for their biomedical applications in the future.

Graphical abstract: The biothiol-triggered organotrisulfide-based self-immolative fluorogenic donors of hydrogen sulfide enable lysosomal trafficking

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Article information


Submitted
22 Jan 2020
Accepted
04 Jun 2020
First published
05 Jun 2020

Chem. Commun., 2020,56, 7769-7772
Article type
Communication

The biothiol-triggered organotrisulfide-based self-immolative fluorogenic donors of hydrogen sulfide enable lysosomal trafficking

S. K. Mahato, D. Bhattacherjee and K. P. Bhabak, Chem. Commun., 2020, 56, 7769
DOI: 10.1039/D0CC00613K

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