Issue 24, 2020
From the journal:

Chemical Communications

An innovative approach for the synthesis of dual modality peptide imaging probes based on the native chemical ligation approach†

Ivan Hawala, ORCID logo a   Lucia De Rosa, ORCID logo b   Silvio Aime ORCID logo a  and  Luca Domenico D’Andrea ORCID logo *c  

* Corresponding authors

a Dipartimento di Biotecnologie Molecolari e Scienze per la Salute, Centro di Imaging Molecolare, Università degli Studi di Torino, Via Nizza 52, Torino (TO), Italy

b Istituto di Biostrutture e Bioimmagini, CNR, Via Mezzocannone 16, 80134 Napoli (NA), Italy

c Istituto di Biostrutture e Bioimmagini, CNR, Via Nizza 52, 10126 Torino (TO), Italy
E-mail: luca.dandrea@cnr.it

Abstract

Peptide-targeting probes tagged with optical imaging and PET reporters may find applications in innovative diagnostic procedures and image-guided surgeries. The reported synthesis procedure is of general applicability to obtain dual imaging probes using fully unprotected moieties with a selective and rapid chemistry based on native chemical ligation.

Graphical abstract: An innovative approach for the synthesis of dual modality peptide imaging probes based on the native chemical ligation approach

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Article information

DOI
https://doi.org/10.1039/C9CC09980H
Article type
Communication
Submitted
25 Dec 2019
Accepted
18 Feb 2020
First published
18 Feb 2020
This article is Open Access
Creative Commons BY-NC license

Chem. Commun., 2020,56, 3500-3503

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An innovative approach for the synthesis of dual modality peptide imaging probes based on the native chemical ligation approach

I. Hawala, L. De Rosa, S. Aime and L. D. D’Andrea, Chem. Commun., 2020, 56, 3500 DOI: 10.1039/C9CC09980H

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