Peroxidation of 3,4-dihydro-1,4-benzoxazin-2-ones

Abstract

The sp³-C–H peroxidation of 3,4-dihydro-1,4-benzoxazin-2-ones was achieved under mild and simple catalyst-free reaction conditions. A range of biologically important alkylated benzoxazinone peroxides are synthesized in high yield with a good functional group tolerance. The C(sp³)-OO bond was constructed efficiently and could be further converted into C(sp³)–C(sp³), C(sp³)–C(sp²), C(sp³)–C(sp), C–P and CO bonds by late-stage functional group transformations.