Issue 6, 2020

Copper-catalysed three-component carboiodination of arynes: expeditious synthesis of o-alkynyl aryl iodides

Abstract

A copper-catalysed three-component iodoalkynylation reaction of arynes for the expeditious and versatile synthesis of o-alkynyl aryl iodides has been developed. Mechanism research shows that the reaction goes through two steps enabled by copper catalysis: the formation of 1-iodo-2-arylacetylene and the insertion of the aryne into a C(sp)–I bond.

Graphical abstract: Copper-catalysed three-component carboiodination of arynes: expeditious synthesis of o-alkynyl aryl iodides

Supplementary files

Article information

Article type
Communication
Submitted
26 Nov 2019
Accepted
12 Dec 2019
First published
13 Dec 2019

Chem. Commun., 2020,56, 972-975

Copper-catalysed three-component carboiodination of arynes: expeditious synthesis of o-alkynyl aryl iodides

W. Cao, S. Niu, L. Shuai and Q. Xiao, Chem. Commun., 2020, 56, 972 DOI: 10.1039/C9CC09160B

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