Light-responsive vesicles for enantioselective release of chiral drugs prepared from a supra-amphiphilic M-helix

Tengfei Yan; Fei Li; Shuaiwei Qi; Jun Tian; Ruizhen Tian; Jinxing Hou; Quan Luo; Zeyuan Dong; Jiayun Xu; Junqiu Liu

doi:10.1039/C9CC08380D

Light-responsive vesicles for enantioselective release of chiral drugs prepared from a supra-amphiphilic M-helix†

Tengfei Yan,‡^a Fei Li,‡^a Shuaiwei Qi,^a Jun Tian,^a Ruizhen Tian,^a Jinxing Hou,^a Quan Luo,

^a Zeyuan Dong,

^a Jiayun Xu^a and Junqiu Liu

*^a

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* Corresponding authors

^a State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, 2699 Qianjin Street, Changchun 130012, China
E-mail: junqiuliu@jlu.edu.cn

Abstract

A kind of light-responsive vesicle was prepared by aqueous self-assembly of α-CD and an azobenzene-containing M-helical foldamer, which displayed dynamic disassembly–reassembly structural transformation when alternately irradiated by UV and visible light. Distinctively, this vesicle also exhibited enantioselective release abilities toward racemic propranolol (a β-blocker), owing to the M-helical building blocks.

Chemical Communications

Light-responsive vesicles for enantioselective release of chiral drugs prepared from a supra-amphiphilic M-helix†

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Light-responsive vesicles for enantioselective release of chiral drugs prepared from a supra-amphiphilic M-helix

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