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Issue 10, 2020
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Peptide-based short single β-strand mimics without hydrogen bonding or aggregation

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Abstract

Generation of short peptides with a single β-strand structure in solution is difficult. Herein, we design a new class of single β-strand peptidic mimics that are stable without self-aggregation in protic and non-protic solvents. Introduction of one present β-strand mimic can induce and propagate the β-strand structure for at least a penta-peptide sequence.

Graphical abstract: Peptide-based short single β-strand mimics without hydrogen bonding or aggregation

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Article information


Submitted
26 Oct 2019
Accepted
19 Dec 2019
First published
19 Dec 2019

Chem. Commun., 2020,56, 1573-1576
Article type
Communication

Peptide-based short single β-strand mimics without hydrogen bonding or aggregation

L. Zhai, Y. Otani, Y. Hori, T. Tomita and T. Ohwada, Chem. Commun., 2020, 56, 1573
DOI: 10.1039/C9CC08378B

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