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Issue 9, 2020
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Iodine promoted cascade cycloisomerization of 1-en-6,11-diynes

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Abstract

An iodine promoted cascade cycloisomerization of 1-en-6,11-diynes is presented for the easy preparation of tetrahydrobenzo[f]isoquinolines. This developed reaction system is identified as having good functional-group applicability and can be scaled up to gram quantities. In this transformation, two new cyclic frameworks and one carbonyl group are formed with four new bonds constructed. Additionally, the resulting iodo-substituted compounds could be further derived through simple elimination reactions.

Graphical abstract: Iodine promoted cascade cycloisomerization of 1-en-6,11-diynes

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Article information


Submitted
22 Oct 2019
Accepted
18 Dec 2019
First published
19 Dec 2019

Chem. Commun., 2020,56, 1421-1424
Article type
Communication

Iodine promoted cascade cycloisomerization of 1-en-6,11-diynes

Y. Qiu, Y. Niu, X. Song, X. Wei, H. Chen, S. Li, X. Wang, C. Huo, Z. Quan and Y. Liang, Chem. Commun., 2020, 56, 1421
DOI: 10.1039/C9CC08286G

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