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Issue 7, 2020
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Simultaneous imaging of mitochondrial viscosity and hydrogen peroxide in Alzheimer's disease by a single near-infrared fluorescent probe with a large Stokes shift

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Abstract

It has been speculated that both the intracellular viscosity and H2O2 level in Alzheimer's disease (AD) brains are higher than that in healthy brains, but direct evidence from living beings is scarce. Herein, we report a NIR emissive fluorescent probe with a large Stokes shift for the associated detection of mitochondrial viscosity and H2O2 in live rat brains with AD for the first time.

Graphical abstract: Simultaneous imaging of mitochondrial viscosity and hydrogen peroxide in Alzheimer's disease by a single near-infrared fluorescent probe with a large Stokes shift

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Article information


Submitted
22 Oct 2019
Accepted
12 Dec 2019
First published
15 Dec 2019

Chem. Commun., 2020,56, 1050-1053
Article type
Communication

Simultaneous imaging of mitochondrial viscosity and hydrogen peroxide in Alzheimer's disease by a single near-infrared fluorescent probe with a large Stokes shift

S. Li, P. Wang, W. Feng, Y. Xiang, K. Dou and Z. Liu, Chem. Commun., 2020, 56, 1050
DOI: 10.1039/C9CC08267K

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