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Issue 1, 2020
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Metal-free α-arylation of α-fluoro-α-nitroacetamides employing diaryliodonium salts

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Abstract

Herein, we present a mild and efficient metal-free arylation of α-fluoro-α-nitroacetamides employing diaryliodonium salts. A broad range of diaryliodonium salts and α-fluoro-α-nitroacetamides containing sensitive functional groups was successfully employed in this protocol to yield the arylated products in good yields. The synthetic value of this novel protocol was further highlighted by extending the α-arylation to α-cyano-α-fluoroacetamides.

Graphical abstract: Metal-free α-arylation of α-fluoro-α-nitroacetamides employing diaryliodonium salts

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Article information


Submitted
07 Oct 2019
Accepted
27 Nov 2019
First published
27 Nov 2019

Chem. Commun., 2020,56, 153-156
Article type
Communication

Metal-free α-arylation of α-fluoro-α-nitroacetamides employing diaryliodonium salts

M. K. Zaheer, E. Gupta, R. Kant and K. Mohanan, Chem. Commun., 2020, 56, 153
DOI: 10.1039/C9CC07859B

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