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Issue 15, 2020
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Biotinylated photoactive Pt(iv) anticancer complexes

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Abstract

Novel biotinylated diazido-Pt(IV) complexes exhibit high visible light photocytotoxicity while being stable in the dark. Photocytotoxicity and cellular accumulation of all-trans-[Pt(py)2(N3)2(biotin)(OH)] (2a) were enhanced significantly when bound to avidin; irradiation induced dramatic cellular morphological changes in human ovarian cancer cells treated with 2a.

Graphical abstract: Biotinylated photoactive Pt(iv) anticancer complexes

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Supplementary files

Article information


Submitted
06 Oct 2019
Accepted
18 Dec 2019
First published
28 Jan 2020

This article is Open Access

Chem. Commun., 2020,56, 2320-2323
Article type
Communication

Biotinylated photoactive Pt(IV) anticancer complexes

H. Shi, C. Imberti, H. Huang, I. Hands-Portman and P. J. Sadler, Chem. Commun., 2020, 56, 2320
DOI: 10.1039/C9CC07845B

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