Donor–acceptor conjugated polymer-based nanoparticles for highly effective photoacoustic imaging and photothermal therapy in the NIR-II window

Zuwu Wei; Fuli Xin; Jian Zhang; Ming Wu; Ting Qiu; Yintao Lan; Shuangying Qiao; Xiaolong Liu; Jingfeng Liu

doi:10.1039/C9CC07821E

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Donor–acceptor conjugated polymer-based nanoparticles for highly effective photoacoustic imaging and photothermal therapy in the NIR-II window†

Zuwu Wei,

^abc Fuli Xin,^d Jian Zhang,

^e Ming Wu,

^abc Ting Qiu,^e Yintao Lan,^e Shuangying Qiao,^f Xiaolong Liu

*^abc and Jingfeng Liu

*^abcd

Author affiliations

* Corresponding authors

^a The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou 350025, P. R. China
E-mail: xiaoloong.liu@gmail.com, drjingfeng@126.com

^b Mengchao Med-X Center, Fuzhou University, Fuzhou 350116, P. R. China

^c The Liver Center of Fujian Province, Fujian Medical University, Fuzhou 350025, P. R. China

^d Liver Disease Center, The First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, P. R. China

^e School of Basic Medical Sciences, Affiliated Stomatology Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou 511436, P. R. China

^f School of Life Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, P. R. China

Abstract

We prepared novel conjugated polymer based NIR-II nanoparticles, which display extremely high photothermal conversion efficiency (65%). Both in vitro and in vivo investigations revealed that the as-prepared nanoparticles exhibit excellent theranostic properties including an extremely high cancer cell killing ability, admirable tumor elimination efficiency (100%) and a remarkable photoacoustic imaging contrast enhancing ability.

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Article information

DOI: https://doi.org/10.1039/C9CC07821E
Article type: Communication
Submitted: 05 Oct 2019
Accepted: 16 Dec 2019
First published: 18 Dec 2019

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Chem. Commun., 2020,56, 1093-1096

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Donor–acceptor conjugated polymer-based nanoparticles for highly effective photoacoustic imaging and photothermal therapy in the NIR-II window

Z. Wei, F. Xin, J. Zhang, M. Wu, T. Qiu, Y. Lan, S. Qiao, X. Liu and J. Liu, Chem. Commun., 2020, 56, 1093 DOI: 10.1039/C9CC07821E

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Chemical Communications

Donor–acceptor conjugated polymer-based nanoparticles for highly effective photoacoustic imaging and photothermal therapy in the NIR-II window†

Abstract

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Donor–acceptor conjugated polymer-based nanoparticles for highly effective photoacoustic imaging and photothermal therapy in the NIR-II window

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