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Issue 99, 2019
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NIRF turn-on nanoparticles based on the tumor microenvironment for monitoring intracellular protein delivery

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Abstract

A dual responsive NIRF turn-on protein delivery system incorporating an NIRF turn-on probe and protein into one single nanoparticle has been constructed. It can be taken up efficiently by A549 cells, where protein release and NIRF recovery happen simultaneously in response to low pH and excessive H2O2. This work provides a novel system for monitoring intracellular protein delivery.

Graphical abstract: NIRF turn-on nanoparticles based on the tumor microenvironment for monitoring intracellular protein delivery

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Article information


Submitted
03 Oct 2019
Accepted
18 Nov 2019
First published
18 Nov 2019

Chem. Commun., 2019,55, 14930-14933
Article type
Communication

NIRF turn-on nanoparticles based on the tumor microenvironment for monitoring intracellular protein delivery

H. Xu, Y. Wang, Z. Pei, W. Ji and Y. Pei, Chem. Commun., 2019, 55, 14930
DOI: 10.1039/C9CC07768E

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