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Issue 91, 2019
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Palladium(ii)-catalyzed oxidative C(sp3)–P bond formation via C(sp3)–H bond activation

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Abstract

Disclosed herein is a Pd(II)-catalyzed C(sp3)–H/P–H oxidative cross-coupling reaction between 8-methylquinolines with H-phosphonates or diarylphosphine oxides via chelation-assisted C(sp3)–H bond activation. The protocol exhibits a relatively broad functional-group tolerance and exclusive chemo- and regioselectivity. Furthermore, detailed mechanistic studies support the proposed reaction pathway.

Graphical abstract: Palladium(ii)-catalyzed oxidative C(sp3)–P bond formation via C(sp3)–H bond activation

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Supplementary files

Article information


Submitted
29 Sep 2019
Accepted
21 Oct 2019
First published
21 Oct 2019

Chem. Commun., 2019,55, 13693-13696
Article type
Communication

Palladium(II)-catalyzed oxidative C(sp3)–P bond formation via C(sp3)–H bond activation

L. Chen, Z. Zhou, S. Zhang, X. Li, X. Ma and J. Dong, Chem. Commun., 2019, 55, 13693
DOI: 10.1039/C9CC07637A

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