Issue 90, 2019
From the journal:

Chemical Communications

A novel distyryl boron dipyrromethene with two functional tags for site-specific bioorthogonal photosensitisation towards targeted photodynamic therapy†

Xuejiao Guo,a   Roy C. H. Wong,b   Yimin Zhou, ORCID logo b   Dennis K. P. Ng ORCID logo b  and  Pui-Chi Lo ORCID logo *ac  

* Corresponding authors

a Department of Biomedical Sciences, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong, China
E-mail: gigi.lo@cityu.edu.hk

b Department of Chemistry, The Chinese University of Hong Kong, Shatin, N. T., Hong Kong, China

c Shenzhen Research Institute of City University of Hong Kong, Shenzhen 518057, China

Abstract

A distyryl boron dipyrromethene based photosensitiser substituted with 1,2,4,5-tetrazine and alkyne moieties was prepared. Through site-specific bioorthogonal reactions with the complementary functional tags anchored on the membrane of A431 human epidermoid carcinoma cells, this versatile photosensitiser exhibited enhanced cellular uptake and photocytotoxicity. The bioorthogonal ligation was also demonstrated in tumour-bearing nude mice.

Graphical abstract: A novel distyryl boron dipyrromethene with two functional tags for site-specific bioorthogonal photosensitisation towards targeted photodynamic therapy

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Article information

DOI
https://doi.org/10.1039/C9CC07460K
Article type
Communication
Submitted
23 Sep 2019
Accepted
04 Oct 2019
First published
05 Oct 2019

Chem. Commun., 2019,55, 13518-13521

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A novel distyryl boron dipyrromethene with two functional tags for site-specific bioorthogonal photosensitisation towards targeted photodynamic therapy

X. Guo, R. C. H. Wong, Y. Zhou, D. K. P. Ng and P. Lo, Chem. Commun., 2019, 55, 13518 DOI: 10.1039/C9CC07460K

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