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Issue 90, 2019
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A novel distyryl boron dipyrromethene with two functional tags for site-specific bioorthogonal photosensitisation towards targeted photodynamic therapy

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Abstract

A distyryl boron dipyrromethene based photosensitiser substituted with 1,2,4,5-tetrazine and alkyne moieties was prepared. Through site-specific bioorthogonal reactions with the complementary functional tags anchored on the membrane of A431 human epidermoid carcinoma cells, this versatile photosensitiser exhibited enhanced cellular uptake and photocytotoxicity. The bioorthogonal ligation was also demonstrated in tumour-bearing nude mice.

Graphical abstract: A novel distyryl boron dipyrromethene with two functional tags for site-specific bioorthogonal photosensitisation towards targeted photodynamic therapy

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Supplementary files

Article information


Submitted
23 Sep 2019
Accepted
04 Oct 2019
First published
05 Oct 2019

Chem. Commun., 2019,55, 13518-13521
Article type
Communication

A novel distyryl boron dipyrromethene with two functional tags for site-specific bioorthogonal photosensitisation towards targeted photodynamic therapy

X. Guo, R. C. H. Wong, Y. Zhou, D. K. P. Ng and P. Lo, Chem. Commun., 2019, 55, 13518
DOI: 10.1039/C9CC07460K

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