Issue 86, 2019
From the journal:

Chemical Communications

Nucleophilic halo-Michael addition under Lewis-base activation†

Víctor Laina-Martín, ORCID logo ‡a   Ignacio Pérez,‡a   Jose A. Fernández-Salas ORCID logo *a  and  José Alemán ORCID logo *ab  

* Corresponding authors

a Organic Chemistry Department, Módulo 1, Universidad Autónoma de Madrid, 28049 Madrid, Spain
E-mail: j.fernandez@uam.es, jose.aleman@uam.es
Web: http://www.uam.es/jose.aleman

b Institute for Advanced Research in Chemical Sciences (IAdChem), Universidad Autónoma de Madrid, 28049 Madrid, Spain

Abstract

A simple and general conjugate nucleophilic halogenation is presented. The THTO/halosilane combination has shown the ability to act as a nucleophilic halide source in the conjugate addition to a variety of Michael acceptors. In addition, a straightforward diastereoselective halogen installation using α,β-unsaturated acyloxazolidinones as platforms has been developed.

Graphical abstract: Nucleophilic halo-Michael addition under Lewis-base activation

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C9CC07068K
Article type
Communication
Submitted
10 Sep 2019
Accepted
02 Oct 2019
First published
02 Oct 2019

Chem. Commun., 2019,55, 12936-12939

Permissions

Request permissions

Nucleophilic halo-Michael addition under Lewis-base activation

V. Laina-Martín, I. Pérez, J. A. Fernández-Salas and J. Alemán, Chem. Commun., 2019, 55, 12936 DOI: 10.1039/C9CC07068K

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements