Issue 88, 2019
From the journal:

Chemical Communications

Monoamine oxidase-A targeting probe for prostate cancer imaging and inhibition of metastasis†

Won Young Kim,‡a   Miae Won, ORCID logo ‡a   Abbas Salimi,‡b   Amit Sharma, ORCID logo a   Jong Hyeon Lim,c   Seung-Hae Kwon,d   Joo-Yeong Jeon,d   Jin Yong Lee ORCID logo *c  and  Jong Seung Kim ORCID logo *a  

* Corresponding authors

a Department of Chemistry, Korea University, Seoul 02841, Korea
E-mail: jongskim@korea.ac.kr

b School of Chemical Engineering, Sungkyunkwan University, Suwon 16419, Korea

c Department of Chemistry, Sungkyunkwan University, Suwon 16419, Korea
E-mail: jinylee@skku.edu

d Seoul Center, Korea Basic Science Institute, Seoul 02841, Korea

Abstract

Mitochondrial enzyme monoamine oxidase (MAO-A) is known to be overexpressed in prostate cancer (PCa) cells. Herein, we have developed a two-photon probe (PCP-1) for selectively targeting and imaging the MAO-A in PCa. Supported by enzymatic docking and in vitro experiments, PCP-1 showed efficiency to visualize MAO-A overexpressing cells and inhibit their growth and metastasis potential.

Graphical abstract: Monoamine oxidase-A targeting probe for prostate cancer imaging and inhibition of metastasis

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Article information

DOI
https://doi.org/10.1039/C9CC07009E
Article type
Communication
Submitted
09 Sep 2019
Accepted
03 Oct 2019
First published
04 Oct 2019

Chem. Commun., 2019,55, 13267-13270

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Monoamine oxidase-A targeting probe for prostate cancer imaging and inhibition of metastasis

W. Y. Kim, M. Won, A. Salimi, A. Sharma, J. H. Lim, S. Kwon, J. Jeon, J. Y. Lee and J. S. Kim, Chem. Commun., 2019, 55, 13267 DOI: 10.1039/C9CC07009E

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