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Issue 88, 2019

Monoamine oxidase-A targeting probe for prostate cancer imaging and inhibition of metastasis

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Abstract

Mitochondrial enzyme monoamine oxidase (MAO-A) is known to be overexpressed in prostate cancer (PCa) cells. Herein, we have developed a two-photon probe (PCP-1) for selectively targeting and imaging the MAO-A in PCa. Supported by enzymatic docking and in vitro experiments, PCP-1 showed efficiency to visualize MAO-A overexpressing cells and inhibit their growth and metastasis potential.

Graphical abstract: Monoamine oxidase-A targeting probe for prostate cancer imaging and inhibition of metastasis

Supplementary files

Article information


Submitted
09 Sep 2019
Accepted
03 Oct 2019
First published
04 Oct 2019

Chem. Commun., 2019,55, 13267-13270
Article type
Communication

Monoamine oxidase-A targeting probe for prostate cancer imaging and inhibition of metastasis

W. Y. Kim, M. Won, A. Salimi, A. Sharma, J. H. Lim, S. Kwon, J. Jeon, J. Y. Lee and J. S. Kim, Chem. Commun., 2019, 55, 13267 DOI: 10.1039/C9CC07009E

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