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Issue 93, 2019
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Inhibiting guanine oxidation and enhancing the excess-electron-transfer efficiency of a pyrene-modified oligonucleotide by introducing an electron-donating group on pyrene

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Abstract

The introduction of an electron-donating group (e.g., methoxy or piperidinyl) onto the pyrene moiety of 5-(pyrenylethynyl)-2′-deoxyuridine (PyU) increases its DNA-mediated reductive electron-transfer efficiency. In addition, these modifications dramatically inhibit photoinduced guanine oxidation.

Graphical abstract: Inhibiting guanine oxidation and enhancing the excess-electron-transfer efficiency of a pyrene-modified oligonucleotide by introducing an electron-donating group on pyrene

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Article information


Submitted
21 Aug 2019
Accepted
16 Oct 2019
First published
23 Oct 2019

Chem. Commun., 2019,55, 14062-14065
Article type
Communication

Inhibiting guanine oxidation and enhancing the excess-electron-transfer efficiency of a pyrene-modified oligonucleotide by introducing an electron-donating group on pyrene

T. Okuda, Y. Kawashima, Y. Kasahara, T. Takagi, J. Yamamoto, S. Iwai and S. Obika, Chem. Commun., 2019, 55, 14062
DOI: 10.1039/C9CC06498B

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