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Issue 82, 2019
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Ruthenium-catalyzed synthesis of N-substituted lactams by acceptorless dehydrogenative coupling of diols with primary amines

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Abstract

Herein, we report the first example of synthesis of N-substituted lactams via an acceptorless dehydrogenative coupling of diols with primary amines in one step, which was enabled by combining Ru3(CO)12 with a hybrid N-heterocyclic carbene–phosphine–phosphine ligand as the catalyst.

Graphical abstract: Ruthenium-catalyzed synthesis of N-substituted lactams by acceptorless dehydrogenative coupling of diols with primary amines

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Article information


Submitted
15 Aug 2019
Accepted
12 Sep 2019
First published
14 Sep 2019

Chem. Commun., 2019,55, 12384-12387
Article type
Communication

Ruthenium-catalyzed synthesis of N-substituted lactams by acceptorless dehydrogenative coupling of diols with primary amines

Y. Zheng, X. Nie, Y. Long, L. Ji, H. Fu, X. Zheng, H. Chen and R. Li, Chem. Commun., 2019, 55, 12384
DOI: 10.1039/C9CC06339K

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