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Issue 80, 2019
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Rapid and room temperature detection of single nucleotide variation with enhanced discrimination by crowding assisted allele specific extension

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Abstract

In this paper we report the kinetics based detection of single nucleotide variation (SNV) at room temperature by allele specific extension with different concentrations and types of crowding agents. In general, the crowding conditions enhanced the specificity in the detection of SNV.

Graphical abstract: Rapid and room temperature detection of single nucleotide variation with enhanced discrimination by crowding assisted allele specific extension

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Publication details

The article was received on 11 Aug 2019, accepted on 10 Sep 2019 and first published on 10 Sep 2019


Article type: Communication
DOI: 10.1039/C9CC06229G
Chem. Commun., 2019,55, 12052-12055

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    Rapid and room temperature detection of single nucleotide variation with enhanced discrimination by crowding assisted allele specific extension

    M. Cui, X. Zhou, X. Chen, W. Zheng, L. Bian, Z. Li and B. Zheng, Chem. Commun., 2019, 55, 12052
    DOI: 10.1039/C9CC06229G

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