Issue 86, 2019
From the journal:

Chemical Communications

A novel Mn–Cu bimetallic complex for enhanced chemodynamic therapy with simultaneous glutathione depletion†

Shuhua Cao, ORCID logo *ab   Jiangli Fan, ORCID logo b   Wen Sun, ORCID logo *b   Fahui Li,c   Kaoxue Li,a   Xishi Taia  and  Xiaojun Peng ORCID logo b  

* Corresponding authors

a College of Chemistry, Chemical and Environmental Engineering, Weifang University, No. 5147 Dongfeng Street, Weifang, China
E-mail: shuhua@wfu.edu.cn

b State Key Laboratory of Fine Chemicals, Dalian University of Technology, No. 2 Linggong Road, Dalian 116024, P. R. China
E-mail: sunwen@dlut.edu.cn

c School of Pharmacy, Weifang Medical University, No. 7166 Baotong Street, Weifang, China

Abstract

A bimetallic complex, containing Mn(II) and Cu(II) moieties, was synthesized for chemodynamic therapy (CDT) of cancer. The complex was capable of generating a hydroxyl radical (˙OH) via a Fenton-like reaction involving a Mn complex, and simultaneously depleting glutathione via a Cu complex induced oxidative reaction, thereby enhancing the efficiency of CDT.

Graphical abstract: A novel Mn–Cu bimetallic complex for enhanced chemodynamic therapy with simultaneous glutathione depletion

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Article information

DOI
https://doi.org/10.1039/C9CC06040E
Article type
Communication
Submitted
03 Aug 2019
Accepted
02 Oct 2019
First published
02 Oct 2019

Chem. Commun., 2019,55, 12956-12959

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A novel Mn–Cu bimetallic complex for enhanced chemodynamic therapy with simultaneous glutathione depletion

S. Cao, J. Fan, W. Sun, F. Li, K. Li, X. Tai and X. Peng, Chem. Commun., 2019, 55, 12956 DOI: 10.1039/C9CC06040E

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