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Issue 86, 2019
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A novel Mn–Cu bimetallic complex for enhanced chemodynamic therapy with simultaneous glutathione depletion

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Abstract

A bimetallic complex, containing Mn(II) and Cu(II) moieties, was synthesized for chemodynamic therapy (CDT) of cancer. The complex was capable of generating a hydroxyl radical (˙OH) via a Fenton-like reaction involving a Mn complex, and simultaneously depleting glutathione via a Cu complex induced oxidative reaction, thereby enhancing the efficiency of CDT.

Graphical abstract: A novel Mn–Cu bimetallic complex for enhanced chemodynamic therapy with simultaneous glutathione depletion

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The article was received on 03 Aug 2019, accepted on 02 Oct 2019 and first published on 02 Oct 2019


Article type: Communication
DOI: 10.1039/C9CC06040E
Chem. Commun., 2019,55, 12956-12959

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    A novel Mn–Cu bimetallic complex for enhanced chemodynamic therapy with simultaneous glutathione depletion

    S. Cao, J. Fan, W. Sun, F. Li, K. Li, X. Tai and X. Peng, Chem. Commun., 2019, 55, 12956
    DOI: 10.1039/C9CC06040E

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