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Issue 91, 2019
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An amphipathic cell penetrating peptide aids cell penetration of cyclosporin A and increases its therapeutic effect in an in vivo mouse model for dry eye disease

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Abstract

Cell penetrating peptide (CPP), LK-3, causes a ca. 10-fold increase in the cell penetration of cyclosporin A (CsA) at nanomolar concentrations. The results of an in vivo dry eye mouse model demonstrated that a 100-fold lower dose of the CsA/LK-3 complex than that of Restasis® is sufficient to cause the same therapeutic effect.

Graphical abstract: An amphipathic cell penetrating peptide aids cell penetration of cyclosporin A and increases its therapeutic effect in an in vivo mouse model for dry eye disease

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Supplementary files

Article information


Submitted
01 Aug 2019
Accepted
28 Sep 2019
First published
02 Oct 2019

Chem. Commun., 2019,55, 13657-13660
Article type
Communication

An amphipathic cell penetrating peptide aids cell penetration of cyclosporin A and increases its therapeutic effect in an in vivo mouse model for dry eye disease

S. Hyun, L. Li, K. C. Yoon and J. Yu, Chem. Commun., 2019, 55, 13657
DOI: 10.1039/C9CC05960A

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