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Issue 81, 2019
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Intercepted dehomologation of aldoses by N-heterocyclic carbene catalysis – a novel transformation in carbohydrate chemistry

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Abstract

The development of an N-heterocyclic carbene (NHC) catalysed intercepted dehomologation of aldoses is reported. The unique selectivity of NHCs for aldehydes is exploited in the complex context of reducing sugars. Examples of strong substrate governance for either intercepted dehomologation or a subsequent redox-lactonisation were identified and mechanistically understood. More importantly, it was shown that catalyst design allowed the tuning of the selectivity of the reaction with structurally unbiased starting materials towards either of the two scenarios.

Graphical abstract: Intercepted dehomologation of aldoses by N-heterocyclic carbene catalysis – a novel transformation in carbohydrate chemistry

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Supplementary files

Article information


Submitted
29 Jul 2019
Accepted
23 Aug 2019
First published
19 Sep 2019

This article is Open Access

Chem. Commun., 2019,55, 12144-12147
Article type
Communication

Intercepted dehomologation of aldoses by N-heterocyclic carbene catalysis – a novel transformation in carbohydrate chemistry

M. Draskovits, H. Kalaus, C. Stanetty and M. D. Mihovilovic, Chem. Commun., 2019, 55, 12144
DOI: 10.1039/C9CC05906G

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