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Issue 71, 2019

Fluorine containing cyclopropanes: synthesis of aryl substituted all-cis 1,2,3-trifluorocyclopropanes, a facially polar motif

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Abstract

The syntheses of substituted all-cis-1,2,3-trifluorocyclopropanes are described for the first time. The three fluorines located on each of the cyclopropyl carbons with a stereochemistry where they are all on the same face of the cyclopropane, imparts a significant polarity to the molecule, and the inherent conformational rigidity and lowering of log P makes this motif attractive for exploration as a substituent for pharmaceuticals and agrochemicals research.

Graphical abstract: Fluorine containing cyclopropanes: synthesis of aryl substituted all-cis 1,2,3-trifluorocyclopropanes, a facially polar motif

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Article information


Submitted
24 Jul 2019
Accepted
09 Aug 2019
First published
09 Aug 2019

Chem. Commun., 2019,55, 10539-10542
Article type
Communication

Fluorine containing cyclopropanes: synthesis of aryl substituted all-cis 1,2,3-trifluorocyclopropanes, a facially polar motif

Z. Fang, D. B. Cordes, A. M. Z. Slawin and D. O'Hagan, Chem. Commun., 2019, 55, 10539 DOI: 10.1039/C9CC05749H

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