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Issue 77, 2019
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Phthalocyanine-based mesoporous organosilica nanoparticles: NIR photodynamic efficiency and siRNA photochemical internalization

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Abstract

Mesoporous organosilica nanoparticles (PHT-PMO) have been prepared from an octa-triethoxysilylated Zn phthalocyanine precursor. These PHT-PMO nanoparticles had no dark toxicity but high phototoxicity when irradiated at 650 nm, and remarkable near-infrared phototoxicity when excited at 760 and 810 nm. The PHT-PMO were then aminated to promote electrostatic complexation with siRNA. Transfection experiments were performed upon NIR irradiation and photochemical internalization was very efficient, leading to 65% luciferase extinction in MCF-7 cancer cells expressing stable luciferase.

Graphical abstract: Phthalocyanine-based mesoporous organosilica nanoparticles: NIR photodynamic efficiency and siRNA photochemical internalization

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Supplementary files

Article information


Submitted
23 Jul 2019
Accepted
03 Sep 2019
First published
03 Sep 2019

Chem. Commun., 2019,55, 11619-11622
Article type
Communication

Phthalocyanine-based mesoporous organosilica nanoparticles: NIR photodynamic efficiency and siRNA photochemical internalization

G. Ekineker, C. Nguyen, S. Bayır, S. Dominguez Gil, Ü. İşci, M. Daurat, A. Godefroy, L. Raehm, C. Charnay, E. Oliviero, V. Ahsen, M. Gary-Bobo, J. Durand and F. Dumoulin, Chem. Commun., 2019, 55, 11619
DOI: 10.1039/C9CC05703J

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