Issue 86, 2019
From the journal:

Chemical Communications

Novel α-ketoamide based diazeniumdiolates as hydrogen peroxide responsive nitric oxide donors with anti-lung cancer activity†

Junjie Fu, ORCID logo ‡a   Jing Han, ORCID logo ‡b   Tingting Meng,a   Jing Huac  and  Jian Yin*a  

* Corresponding authors

a Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi 214122, P. R. China
E-mail: jianyin@jiangnan.edu.cn

b School of Chemistry & Materials Science, Jiangsu Key Laboratory of Green Synthetic Chemistry for Functional Materials, Jiangsu Normal University, Xuzhou 221116, P. R. China

c Wuxi School of Medicine, Jiangnan University, Wuxi, P. R. China

Abstract

A novel type of hydrogen peroxide (H2O2)-activated diazeniumdiolate based on an α-ketoamide moietey was developed as a nitric oxide (NO) donor. KA-NO-4 inhibited lung cancer cells with submicromolar activity. The H2O2-responsive behaviour of KA-NO-4 was thoroughly investigated. The NO-centered mechanism of action of KA-NO-4 was intracellularly studied.

Graphical abstract: Novel α-ketoamide based diazeniumdiolates as hydrogen peroxide responsive nitric oxide donors with anti-lung cancer activity

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Article information

DOI
https://doi.org/10.1039/C9CC05266F
Article type
Communication
Submitted
09 Jul 2019
Accepted
30 Sep 2019
First published
30 Sep 2019

Chem. Commun., 2019,55, 12904-12907

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Novel α-ketoamide based diazeniumdiolates as hydrogen peroxide responsive nitric oxide donors with anti-lung cancer activity

J. Fu, J. Han, T. Meng, J. Hu and J. Yin, Chem. Commun., 2019, 55, 12904 DOI: 10.1039/C9CC05266F

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