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Issue 66, 2019
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A water-soluble AIE-active polyvalent glycocluster: design, synthesis and studies on carbohydrate–lectin interactions for visualization of Siglec distributions in living cell membranes

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Abstract

In this work, we designed and synthesized an aggregation-induced emission (AIE)-active tetraphenylethene-decorated pseudo-trisialic acid (TPE3S) and validated its high affinity for Siglecs using microscale thermophoresis techniques. TPE3S was a unique binding-on fluorescent trivalent sialocluster which was successfully utilized for the visualization of Siglecs expressed on the surface of mammalian cells.

Graphical abstract: A water-soluble AIE-active polyvalent glycocluster: design, synthesis and studies on carbohydrate–lectin interactions for visualization of Siglec distributions in living cell membranes

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Article information


Submitted
30 Jun 2019
Accepted
22 Jul 2019
First published
22 Jul 2019

Chem. Commun., 2019,55, 9869-9872
Article type
Communication

A water-soluble AIE-active polyvalent glycocluster: design, synthesis and studies on carbohydrate–lectin interactions for visualization of Siglec distributions in living cell membranes

G. Liu, Y. Zhang, L. Zhou, L. Jia, G. Jiang, G. Xing and S. Wang, Chem. Commun., 2019, 55, 9869
DOI: 10.1039/C9CC05008F

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