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Issue 73, 2019
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Photoinduced synthesis of fluorinated dibenz[b,e]azepines via radical triggered cyclization

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Abstract

A simple, mild and efficient approach to access fluorinated dibenz[b,e]azepines via visible-light photoredox catalysis is presented. Inexpensive and commercially available fluoroalkyl anhydrides in concert with pyridine N-oxide are employed as the source of the fluoroalkyl radicals. A one-pot process involving the trifluoroacetylation of unprotected secondary benzyl amines followed by radical cyclization could also afford the desired fluorinated dibenz[b,e]azepines.

Graphical abstract: Photoinduced synthesis of fluorinated dibenz[b,e]azepines via radical triggered cyclization

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Publication details

The article was received on 28 Jun 2019, accepted on 12 Aug 2019 and first published on 12 Aug 2019


Article type: Communication
DOI: 10.1039/C9CC04977K
Chem. Commun., 2019,55, 10848-10851

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    Photoinduced synthesis of fluorinated dibenz[b,e]azepines via radical triggered cyclization

    X. Qi, H. Zhang, Z. Pan, R. Liang, C. Zhu, J. Li, Q. Tong, X. Gao, L. Wu and J. Zhong, Chem. Commun., 2019, 55, 10848
    DOI: 10.1039/C9CC04977K

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