Issue 74, 2019
From the journal:

Chemical Communications

Cuprous binding promotes interaction of copper transport protein hCTR1 with cell membranes†

Yang Yang,a   Yang Zhu,a   Hongze Hu,a   Lanjun Cheng,a   Manman Liu,a   Guolin Ma,b   Siming Yuan,*a   Peixin Cui*c  and  Yangzhong Liu ORCID logo *a  

* Corresponding authors

a CAS High Magnetic Field Laboratory, Department of Chemistry, University of Science and Technology of China, Hefei Anhui, China
E-mail: liuyz@ustc.edu.cn

b Institute of Biosciences and Technology, College of Medicine, Texas A&M University, 2121 W Holcombe Blvd, Houston, TX 77030, USA

c Key Laboratory of Soil Environment and Pollution Remediation, Institute of Soil Science, the Chinese Academy of Sciences, Nanjing 210008, China

Abstract

Cu(I) binds to the N-terminal metal binding domain (MBD) of hCTR1 and induces its conformational change, which promotes the interaction of the MBD with cell membranes. The membrane interaction was confirmed in living cells. This process could be the first step to initiate the cellular uptake of copper ions by hCTR1.

Graphical abstract: Cuprous binding promotes interaction of copper transport protein hCTR1 with cell membranes

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Article information

DOI
https://doi.org/10.1039/C9CC04859F
Article type
Communication
Submitted
25 Jun 2019
Accepted
16 Aug 2019
First published
19 Aug 2019

Chem. Commun., 2019,55, 11107-11110

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Cuprous binding promotes interaction of copper transport protein hCTR1 with cell membranes

Y. Yang, Y. Zhu, H. Hu, L. Cheng, M. Liu, G. Ma, S. Yuan, P. Cui and Y. Liu, Chem. Commun., 2019, 55, 11107 DOI: 10.1039/C9CC04859F

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