Issue 72, 2019
From the journal:

Chemical Communications

Two-photon fluorescence imaging of mitochondrial superoxide anion transport mediating liver ischemia-reperfusion injury in mice†

Wen Zhang,‡a   Di Su,‡a   Ping Li,*a   Jiao Zhang,a   Jihong Liu,a   Hui Wang,a   Wei Zhanga  and  Bo Tang ORCID logo *a  

* Corresponding authors

a College of Chemistry, Chemical Engineering and Materials Science, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Institutes of Biomedical Sciences, Shandong Normal University, Jinan 250014, People's Republic of China
E-mail: lip@sdnu.edu.cn, tangb@sdnu.edu.cn

Abstract

We constructed a two-photon fluorescence ratio probe (CST) for in situ quantitative real-time detection of mitochondrial O2˙−. Fluorescence imaging showed that O2˙− was over-generated from mitochondria and conveyed to the cytoplasm via voltage-dependent anion channels in hepatic ischemia-reperfusion mice, damaging the important functional protein aconitase in the cytoplasm.

Graphical abstract: Two-photon fluorescence imaging of mitochondrial superoxide anion transport mediating liver ischemia-reperfusion injury in mice

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Article information

DOI
https://doi.org/10.1039/C9CC04585F
Article type
Communication
Submitted
15 Jun 2019
Accepted
08 Aug 2019
First published
09 Aug 2019

Chem. Commun., 2019,55, 10740-10743

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Two-photon fluorescence imaging of mitochondrial superoxide anion transport mediating liver ischemia-reperfusion injury in mice

W. Zhang, D. Su, P. Li, J. Zhang, J. Liu, H. Wang, W. Zhang and B. Tang, Chem. Commun., 2019, 55, 10740 DOI: 10.1039/C9CC04585F

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