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Issue 56, 2019
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Selective RNA interference and gene silencing using reactive oxygen species-responsive lipid nanoparticles

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Abstract

Lipid-complexed small interfering RNA (siRNA) nanoparticles are promising gene regulation materials with excellent genetic, but little cellular, selectivity. Herein, we report a chemical strategy to enhance the gene silencing selectivity of these nanoparticles against cancer cells through the covalent integration of a reactive oxygen species (ROS)-degradable thioketal into the lipid nanoparticles. These lipid nanoparticles can efficiently deliver siRNA into cells, and selectively silence cancer cell gene expression in response to the high levels of intracellular ROS in cancer cells.

Graphical abstract: Selective RNA interference and gene silencing using reactive oxygen species-responsive lipid nanoparticles

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Supplementary files

Article information


Submitted
12 Jun 2019
Accepted
13 Jun 2019
First published
13 Jun 2019

Chem. Commun., 2019,55, 8170-8173
Article type
Communication

Selective RNA interference and gene silencing using reactive oxygen species-responsive lipid nanoparticles

C. Liang, J. Chang, Y. Jiang, J. Liu, L. Mao and M. Wang, Chem. Commun., 2019, 55, 8170
DOI: 10.1039/C9CC04517A

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