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Issue 63, 2019
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Highly enantioselective sequential vinylogous aldol reaction/transesterification of methyl-substituted olefinic butyrolactones with isatins for the construction of chiral spirocyclic oxindole-dihydropyranones

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Abstract

A highly stereoselective sequential vinylogous aldol reaction/transesterification of methyl-substituted olefinic butyrolactones and isatins was developed. With this developed protocol, a series of chiral spirocyclic oxindole-dihydropyranones were obtained in good to excellent yields (73–99%) and enantioselectivities (71–97% ee).

Graphical abstract: Highly enantioselective sequential vinylogous aldol reaction/transesterification of methyl-substituted olefinic butyrolactones with isatins for the construction of chiral spirocyclic oxindole-dihydropyranones

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Article information


Submitted
10 Jun 2019
Accepted
09 Jul 2019
First published
09 Jul 2019

Chem. Commun., 2019,55, 9327-9330
Article type
Communication

Highly enantioselective sequential vinylogous aldol reaction/transesterification of methyl-substituted olefinic butyrolactones with isatins for the construction of chiral spirocyclic oxindole-dihydropyranones

Z. Wang, X. Zhang, C. Lei, J. Zhao, Y. You and W. Yuan, Chem. Commun., 2019, 55, 9327
DOI: 10.1039/C9CC04427B

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