Issue 61, 2019

Flavonoid–alkylphospholipid conjugates elicit dual inhibition of cancer cell growth and lipid accumulation

Abstract

Cancer development is often associated with lipid metabolic reprogramming, including aberrant lipid accumulation. We create novel paradigms endowed with dual functions of anticancer activity and inhibition of lipid accumulation by conjugating the natural product quercetin and synthetic alkylphospholipid drugs, and harnessing the biomedical effects of both. These conjugates offer fresh perspectives in the search for anticancer candidates.

Graphical abstract: Flavonoid–alkylphospholipid conjugates elicit dual inhibition of cancer cell growth and lipid accumulation

Supplementary files

Article information

Article type
Communication
Submitted
27 May 2019
Accepted
14 Jun 2019
First published
04 Jul 2019
This article is Open Access
Creative Commons BY license

Chem. Commun., 2019,55, 8919-8922

Flavonoid–alkylphospholipid conjugates elicit dual inhibition of cancer cell growth and lipid accumulation

Z. Zhou, B. Luo, X. Liu, M. Chen, W. Lan, J. L. Iovanna, L. Peng and Y. Xia, Chem. Commun., 2019, 55, 8919 DOI: 10.1039/C9CC04084F

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