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Issue 59, 2019
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Cu-Catalyzed highly selective reductive functionalization of 1,3-diene using H2O as a stoichiometric hydrogen atom donor

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Abstract

A copper-catalyzed highly regio- and diastereo-selective reductive reaction of terminal 1,3-diene with water and aldehyde has been developed. This chemistry afforded a product containing a terminal alkenyl group, which is a versatile kind of precursor for organic synthesis, with the scope for various substrates. The present reaction system could realize the catalytic transfer of hydrogen to diene using water as a stoichiometric H atom donor. In this transformation, B2Pin2, a mild and practical kind of reductant was used as the mediator. The reaction pathway of this practical strategy was illustrated by a control experiment.

Graphical abstract: Cu-Catalyzed highly selective reductive functionalization of 1,3-diene using H2O as a stoichiometric hydrogen atom donor

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Publication details

The article was received on 24 May 2019, accepted on 25 Jun 2019 and first published on 26 Jun 2019


Article type: Communication
DOI: 10.1039/C9CC04011K
Chem. Commun., 2019,55, 8651-8654

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    Cu-Catalyzed highly selective reductive functionalization of 1,3-diene using H2O as a stoichiometric hydrogen atom donor

    Q. Li, X. Jiao, M. Xing, P. Zhang, Q. Zhao and C. Zhang, Chem. Commun., 2019, 55, 8651
    DOI: 10.1039/C9CC04011K

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