Issue 58, 2019

Rhodium(iii)-catalysed carboxylate-directed C–H functionalizations of isoxazoles with alkynes

Abstract

An efficient oxidative [4+2] annulation of isoxazolyl-4-carboxylic acids with internal alkynes proceeded in the presence of the [Cp*RhCl2]2 catalyst. Oxidants controlled the formation of pyranoisoxazolones and isoquinolines. A decarboxylative approach for the hydroarylation of alkynes with isoxazolyl-4-carboxylic acids was also developed in the presence of the [Cp*Rh(CH3CN)3][SbF6]2 catalyst.

Graphical abstract: Rhodium(iii)-catalysed carboxylate-directed C–H functionalizations of isoxazoles with alkynes

Supplementary files

Article information

Article type
Communication
Submitted
30 Apr 2019
Accepted
10 Jun 2019
First published
10 Jun 2019

Chem. Commun., 2019,55, 8382-8385

Rhodium(III)-catalysed carboxylate-directed C–H functionalizations of isoxazoles with alkynes

S. Yugandar and H. Nakamura, Chem. Commun., 2019, 55, 8382 DOI: 10.1039/C9CC03283E

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