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Issue 61, 2019
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para-Sulphonato-calix[n]arene capped silver nanoparticles challenge the catalytic efficiency and the stability of a novel human gut serine protease inhibitor

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Abstract

The Eubacterium saburreum serine protease inhibitor from the human gut microbiota inhibits the eukaryotic pancreatic elastase associated with acute pancreatitis. Interestingly, the inhibition efficiency and stability are markedly increased by the para-sulphonato-calix[8]arene capped silver nanoparticles. Moreover, this enzyme is distinguishable by its high inhibitory effect at broad pH range between 2–10 and temperatures from 10 to 40 °C, in the presence of para-sulphonato-calix[8]arene capped silver nanoparticles the enzyme remains active even at 70 °C.

Graphical abstract: para-Sulphonato-calix[n]arene capped silver nanoparticles challenge the catalytic efficiency and the stability of a novel human gut serine protease inhibitor

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Article information


Submitted
25 Apr 2019
Accepted
01 Jul 2019
First published
01 Jul 2019

Chem. Commun., 2019,55, 8935-8938
Article type
Communication

para-Sulphonato-calix[n]arene capped silver nanoparticles challenge the catalytic efficiency and the stability of a novel human gut serine protease inhibitor

N. Akermi, H. Mkaouar, A. Kriaa, A. Jablaoui, S. Soussou, A. Gargouri, A. W. Coleman, F. Perret, E. Maguin and M. Rhimi, Chem. Commun., 2019, 55, 8935
DOI: 10.1039/C9CC03183A

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