Methylene chain ruler for evaluating the regioselectivity of a substrate-recognising oxidation catalyst

Shota Teramae; Akane Kito; Tomoteru Shingaki; Yu Hamaguchi; Yuuki Yano; Takamori Nakayama; Yuko Kobayashi; Nobuki Kato; Naoki Umezawa; Yosuke Hisamatsu; Tetsuo Nagano; Tsunehiko Higuchi

doi:10.1039/C9CC03041G

Methylene chain ruler for evaluating the regioselectivity of a substrate-recognising oxidation catalyst†

Shota Teramae,‡^a Akane Kito,‡^a Tomoteru Shingaki,^b Yu Hamaguchi,^a Yuuki Yano,^a Takamori Nakayama,^a Yuko Kobayashi,^a Nobuki Kato,^a Naoki Umezawa,

^a Yosuke Hisamatsu,

^a Tetsuo Nagano^b and Tsunehiko Higuchi

*^a

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* Corresponding authors

^a Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-dori, Mizuho-ku, Nagoya, Aichi 467-8603, Japan
E-mail: higuchi@phar.nagoya-cu.ac.jp

^b Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan

Abstract

Regioselective C–H oxidation of aliphatic molecules with synthetic catalysts is challenging. We incorporated substrate-recognition sites into a ruthenium porphyrin–heteroaromatic N-oxide catalytic system in order to characterise its regioselectivity for the oxidation of alkanes. This substrate-recognition catalytic reaction exhibits high regioselectivity and high reaction efficiency.

Chemical Communications

Methylene chain ruler for evaluating the regioselectivity of a substrate-recognising oxidation catalyst†

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Methylene chain ruler for evaluating the regioselectivity of a substrate-recognising oxidation catalyst

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