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Issue 60, 2019
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Ru(TAP)32+ uses multivalent binding to accelerate and constrain photo-adduct formation on DNA

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Abstract

Ru(II)-complexes with polyazaaromatic ligands can undergo direct electron transfer with guanine nucleobases on blue light excitation that results in DNA lesions with phototherapeutic potential. Here we use single molecule approaches to demonstrate DNA binding mode heterogeneity and evaluate how multivalent binding governs the photochemistry of [Ru(TAP)3]2+ (TAP = 1,4,5,8-tetraazaphenanthrene).

Graphical abstract: Ru(TAP)32+ uses multivalent binding to accelerate and constrain photo-adduct formation on DNA

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Supplementary files

Article information


Submitted
12 Apr 2019
Accepted
17 May 2019
First published
17 May 2019

Chem. Commun., 2019,55, 8764-8767
Article type
Communication

Ru(TAP)32+ uses multivalent binding to accelerate and constrain photo-adduct formation on DNA

W. Vanderlinden, P. J. Kolbeck, W. Frederickx, S. F. Konrad, T. Nicolaus, C. Lampe, A. S. Urban, C. Moucheron and J. Lipfert, Chem. Commun., 2019, 55, 8764
DOI: 10.1039/C9CC02838B

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