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Issue 49, 2019
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Monitoring matrix metalloproteases based on the selective interaction between an Ir(iii) solvent complex and a histidine-rich polypeptide

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Abstract

A luminescent biosensor has been developed for matrix metalloproteinase 9 (MMP-9) assays based on the selective interaction between an Ir(III) solvent complex and a histidine-rich peptide, which avoids the complicated double labeling of substrate polypeptides commonly-used in FRET MMP detections and provides a promising strategy for MMP detection in clinical applications.

Graphical abstract: Monitoring matrix metalloproteases based on the selective interaction between an Ir(iii) solvent complex and a histidine-rich polypeptide

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Article information


Submitted
08 Apr 2019
Accepted
23 May 2019
First published
23 May 2019

Chem. Commun., 2019,55, 7085-7088
Article type
Communication

Monitoring matrix metalloproteases based on the selective interaction between an Ir(III) solvent complex and a histidine-rich polypeptide

H. Su, M. Zang, L. Lu and F. Li, Chem. Commun., 2019, 55, 7085
DOI: 10.1039/C9CC02718A

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