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Issue 42, 2019
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Phosphinate-containing rhodol and fluorescein scaffolds for the development of bioprobes

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Abstract

A series of phosphinate-containing rhodol and fluorescein dyes are disclosed. These new fluorophores increase the color palette of phosphinate-based xanthenes in the far-red spectral region. The new chemical functionality of these scaffolds is leveraged to produce a sensitive, no-wash imaging probe for cellular esterase activity. The reported phosphinate-containing dyes provide platforms for the further development of imaging probes and self-reporting delivery vehicles.

Graphical abstract: Phosphinate-containing rhodol and fluorescein scaffolds for the development of bioprobes

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Supplementary files

Article information


Submitted
31 Mar 2019
Accepted
25 Apr 2019
First published
29 Apr 2019

Chem. Commun., 2019,55, 5962-5965
Article type
Communication

Phosphinate-containing rhodol and fluorescein scaffolds for the development of bioprobes

Y. Fang, G. N. Good, X. Zhou and C. I. Stains, Chem. Commun., 2019, 55, 5962
DOI: 10.1039/C9CC02492A

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