Issue 45, 2019

Copper-catalyzed [4+1]-annulation of 2-alkenylindoles with diazoacetates: a facile access to dihydrocyclopenta[b]indoles

Abstract

A copper-catalyzed [4+1]-annulation of 2-vinylindoles with diazoacetates has been developed that provides a straightforward access to the dihydrocyclopenta[b]indoles bearing two contiguous all-carbon quaternary centers in good yields. Mechanistic studies indicate that the reaction goes through a concerted and asynchronous annulation process via the key zwitterionic intermediate.

Graphical abstract: Copper-catalyzed [4+1]-annulation of 2-alkenylindoles with diazoacetates: a facile access to dihydrocyclopenta[b]indoles

Supplementary files

Article information

Article type
Communication
Submitted
22 Mar 2019
Accepted
08 May 2019
First published
09 May 2019

Chem. Commun., 2019,55, 6393-6396

Copper-catalyzed [4+1]-annulation of 2-alkenylindoles with diazoacetates: a facile access to dihydrocyclopenta[b]indoles

K. Dong, C. Pei, Q. Zeng, L. Qiu, W. Hu, Y. Qian and X. Xu, Chem. Commun., 2019, 55, 6393 DOI: 10.1039/C9CC02257K

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