Issue 35, 2019
From the journal:

Chemical Communications

Programming a split G-quadruplex in a DNA nanocage and its microRNA imaging in live cells†

Yanyan Yu,a   Yao Zhou,a   Min Zhu,a   Mingkai Liu,b   Hongyan Zhu,a   Yong Chen,a   Gaoxing Su,*a   Wei Chen ORCID logo *c  and  Huaping Peng*c  

* Corresponding authors

a School of Pharmacy, Nantong University, Nantong, Jiangsu 226001, China
E-mail: sugaoxing@ntu.edu.cn

b School of Chemistry & Materials Science, Jiangsu Key Laboratory of Green Synthetic Chemistry for Functional Materials, Jiangsu Normal University, Xuzhou 221116, China

c School of Pharmacy, Fujian Medical University, Fuzhou, Fujian 350004, China
E-mail: chenandhu@163.com, phpfjmu@126.com

Abstract

A novel approach to program target-responsive devices by incorporating the split G4 motifs in a DNA nanocage has been developed. The rigid prism outcompetes the flexible one in reaction kinetics and signal/background ratios, which can be easily internalized by cells and successfully applied in microRNA imaging in live cells.

Graphical abstract: Programming a split G-quadruplex in a DNA nanocage and its microRNA imaging in live cells

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Article information

DOI
https://doi.org/10.1039/C9CC02096A
Article type
Communication
Submitted
14 Mar 2019
Accepted
01 Apr 2019
First published
01 Apr 2019

Chem. Commun., 2019,55, 5131-5134

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Programming a split G-quadruplex in a DNA nanocage and its microRNA imaging in live cells

Y. Yu, Y. Zhou, M. Zhu, M. Liu, H. Zhu, Y. Chen, G. Su, W. Chen and H. Peng, Chem. Commun., 2019, 55, 5131 DOI: 10.1039/C9CC02096A

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