Jump to main content
Jump to site search

Issue 52, 2019
Previous Article Next Article

Theragnosis by a miR-141-3p molecular beacon: simultaneous detection and sensitization of 5-fluorouracil resistant colorectal cancer cells through the activation of the TRIM13-associated apoptotic pathway

Author affiliations

Abstract

We developed a molecular beacon targeting miR-141-3p, aberrantly increased in 5-fluorouracil-resistant colorectal cancer cells (R-CRCCs). It consists of a fluorophore-labeled oligonucleotide, antisense to miR-141-3p, and a quencher. It detected R-CRCCs and recovered the chemosensitivity of them to 5-fluorouracil by hybridization with miR-141-3p, which is applicable to cancer treatment.

Graphical abstract: Theragnosis by a miR-141-3p molecular beacon: simultaneous detection and sensitization of 5-fluorouracil resistant colorectal cancer cells through the activation of the TRIM13-associated apoptotic pathway

Back to tab navigation

Supplementary files

Article information


Submitted
16 Mar 2019
Accepted
30 May 2019
First published
31 May 2019

Chem. Commun., 2019,55, 7466-7469
Article type
Communication

Theragnosis by a miR-141-3p molecular beacon: simultaneous detection and sensitization of 5-fluorouracil resistant colorectal cancer cells through the activation of the TRIM13-associated apoptotic pathway

S. U. Moon, Y. Park, M. G. Park, S. K. Song, S. H. Jeong, Y. S. Lee, H. J. Heo, W. Y. Jung and S. Kim, Chem. Commun., 2019, 55, 7466
DOI: 10.1039/C9CC01944H

Social activity

Search articles by author

Spotlight

Advertisements