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Issue 38, 2019
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Site-selective C(sp3)–H amination of thioamide with anthranils under Cp*CoIII catalysis

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Abstract

Synthetically versatile anthranils as a bifunctional amino source have been employed for the first time to enable direct amination on unactivated C(sp3)–H bonds of thioamides under Cp*CoIII catalysis. The excellent site-selectivity on primary C(sp3)–H bonds is observed for a diverse array of thioamides with high functional group tolerance. Further applicability of the products is also highlighted through a series of interesting synthetic elaborations.

Graphical abstract: Site-selective C(sp3)–H amination of thioamide with anthranils under Cp*CoIII catalysis

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Supplementary files

Article information


Submitted
04 Mar 2019
Accepted
16 Apr 2019
First published
22 Apr 2019

Chem. Commun., 2019,55, 5519-5522
Article type
Communication

Site-selective C(sp3)–H amination of thioamide with anthranils under Cp*CoIII catalysis

R. Liu, Q. Shan, X. Hu and T. Loh, Chem. Commun., 2019, 55, 5519
DOI: 10.1039/C9CC01715A

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